Article
The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.
The Journal of biological chemistry - 28 Apr 2006
Sutherland Catherine M, Moretti Paul A B, Hewitt Niamh M, Bagley Christopher J, Vadas Mathew A, Pitson Stuart M
Abstract excerpt
Sphingosine kinases catalyze the formation of sphingosine 1-phosphate, a bioactive lipid involved in many aspects of cellular regulation, including the fundamental biological processes of cell growth and survival. A diverse range of cell agonists induce activation of human sphingosine kinase 1 (hSK1) and, commonly, its translocation to the plasma membrane. Although the activation of hSK1 in response to at least...
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