Article

Structural dynamics of sphingosine kinase 1 regulation and inhibition

2025-05-07

Abstract excerpt

<title>Abstract</title> <p>Sphingosine kinase 1 (SK1) produces sphingosine-1-phosphate, a bioactive lipid implicated in cancer progression and other diseases. Despite its clinical relevance, the structural and dynamic basis of SK1 regulation and inhibition remains poorly understood. Using an integrated spectroscopic and computational approach, we uncover conformational transitions that govern substrate entry, cat...

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Literature Corpus work: 1aa148ce-26ac-5739-a8b0-25193b449cac
DOI: 10.21203/rs.3.rs-6575060/v1

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