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Article

The nucleotide-binding site of human sphingosine kinase 1.

The Journal of biological chemistry - 20 Dec 2002

Pitson Stuart M, Moretti Paul A B, Zebol Julia R, Zareie Reza, Derian Claudia K, Darrow Andrew L, Qi Jenson, D'Andrea Richard J, Bagley Christopher J, Vadas Mathew A, Wattenberg Binks W

Abstract excerpt

Sphingosine kinase catalyzes the formation of sphingosine 1-phosphate, a lipid second messenger that has been implicated in a number of agonist-driven cellular responses including mitogenesis, anti-apoptosis, and expression of inflammatory molecules. Despite the importance of sphingosine kinase, very little is known regarding its structure or mechanism of catalysis. Moreover, sphingosine kinase does not contain...

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PMID: 12393916
DOI: 10.1074/jbc.M206687200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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