Article
Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2005
Fieger Claudia B, Huang Mei-Chuan, Van Brocklyn James R, Goetzl Edward J
Abstract excerpt
The type 1 sphingosine 1-phosphate (S1P) G protein-coupled receptor (S1P1) transduces signals from S1P that mediate thymocyte emigration, T cell transmigration of lymph nodes, and T cell chemotaxis in tissues. Alterations in expression of functional S1P1 receptors by lymphocytes are the major mechanisms controlling their responses to S1P and were thought to be solely a consequence of the balance between surface...
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