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Article

Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

The Journal of biological chemistry - 15 Dec 2000

Parrill A L, Wang D, Bautista D L, Van Brocklyn J R, Lorincz Z, Fischer D J, Baker D L, Liliom K, Spiegel S, Tigyi G

Abstract excerpt

Originating from its DNA sequence, a computational model of the Edg1 receptor has been developed that predicts critical interactions with its ligand, sphingosine 1-phosphate. The basic amino acids Arg(120) and Arg(292) ion pair with the phosphate, whereas the acidic Glu(121) residue ion pairs with the ammonium moiety of sphingosine 1-phosphate. The requirement of these interactions for specific ligand recognition...

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Identifiers

PMID: 10982820
DOI: 10.1074/jbc.M007680200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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