Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin.

doi:10.1111/j.1432-1033.1997.00459.x

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Article

Structural requirements of phospholipase C delta1 for regulation by spermine, sphingosine and sphingomyelin.

European journal of biochemistry - 1 Sept 1997

Pawelczyk T, Matecki A

Abstract excerpt

We studied the relationship between sphingomyelin, calcium, spermine and sphingosine in regulation of phospholipase C (PLC) delta1 activity. Inhibition of PLC delta1 by sphingomyelin was promoted by spermine and Ca2+ and was partially abolished by sphingosine. The effect of sphingosine and spermi...

Topics

Binding Sites
Calcium
Isoenzymes
Kinetics
Mutation
Phospholipase C delta
Recombinant Proteins
Sequence Deletion
Spermine
Sphingomyelins
Sphingosine
Trypsin
Type C Phospholipases

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