Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells.

Abstract excerpt

Sphingosine 1-phosphate (S1P), a lysophospholipid mediator, regulates diverse functions of many types of cells by binding to specific G protein-coupled receptors termed S1P(1)-S1P(5). In T-cells, tyrosine sulphation of S1P(1) is required for high-affinity binding of S1P and fully functional signalling. In this study, we showed that tyrosine sulphation of S1P(1) is necessary for S1P-induced Src phosphorylation and...

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