Article
Identification of discrete segments of human Raf-1 kinase critical for high affinity binding to Ha-Ras.
The Journal of biological chemistry - 9 Dec 1994
Ghosh S, Bell R M
Abstract excerpt
A critical event in a signal transduction pathway downstream of receptor tyrosine kinases is the physical association of GTP-liganded Ras with the serine/threonine kinase, Raf-1. The binding of Raf-1 to Ras results in translocation of the kinase to the plasma membrane and facilitates its activation by an unknown mechanism. A deletion mutagenesis approach was employed to elucidate critical sequences in Raf-1...
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