Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor.

European journal of pharmacology - 30 Sept 2011

van Loenen Pieter B, de Graaf Chris, Verzijl Dennis, Leurs Rob, Rognan Didier, Peters Stephan L M, Alewijnse Astrid E

Abstract excerpt

The sphingosine-1-phosphate type 1 (S1P(1)) receptor is a new target in the treatment of auto-immune diseases as evidenced by the recent approval of FTY720 (Fingolimod). The ligand-binding pocket of the S1P(1) receptor has been generally characterised but detailed insight into ligand-specific differences is still lacking. The aim of the current study is to determine differences in ligand-induced S1P(1) receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Models, Molecular

Share to Mutagenesis, Site-Directed

Share to Protein Conformation

Share to Protein Stability

Share to Stereoisomerism

Source

Identifiers

PMID: 21663738
DOI: 10.1016/j.ejphar.2011.05.071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Agonist-dependent effects of mutations in the sphingosine-1-phosphate type 1 receptor.PMID 21663738Read ↗

S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate.Semantic proximity Read ↗

In-silico characterization of deleterious non-synonymous SNPs in the human S1PR1 gene reveals structural instability and altered ligand affinity.Semantic proximity Read ↗

Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.Semantic proximity Read ↗

Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.Semantic proximity Read ↗

Pseudoirreversible inhibition elicits persistent efficacy of a sphigosine-1-phosphate receptor-1 antagonistSemantic proximity Read ↗

A sphingosine 1-phosphate receptor 2 selective allosteric agonist.Semantic proximity Read ↗

Individual variation of human S1P₁ coding sequence leads to heterogeneity in receptor function and drug interactions.Semantic proximity Read ↗

Structural dynamics of sphingosine kinase 1 regulation and inhibitionSemantic proximity Read ↗

Structural dynamics of sphingosine kinase 1 regulation and inhibitionSemantic proximity Read ↗

Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors.Semantic proximity Read ↗

Differential impact of amino acid substitutions on critical residues of the human glucagon-like peptide-1 receptor involved in peptide activity and small-molecule allostery.Semantic proximity Read ↗

TRPML1 gating modulation by allosteric mutations and lipids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.