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Article

Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine.

The Journal of biological chemistry - 29 Aug 2003

Qiu Huawei, Edmunds Tim, Baker-Malcolm Jennifer, Karey Kenneth P, Estes Scott, Schwarz Cordula, Hughes Heather, Van Patten Scott M

Abstract excerpt

One form of Niemann-Pick disease is caused by a deficiency in the enzymatic activity of acid sphingomyelinase. During efforts to develop an enzyme replacement therapy based on a recombinant form of human acid sphingomyelinase (rhASM), purified preparations of the recombinant enzyme were found to...

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Source

Identifiers

PMID: 12801930
DOI: 10.1074/jbc.M303022200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12801930-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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