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Article

The mechanism of membrane targeting of human sphingosine kinase 1.

The Journal of biological chemistry - 30 Dec 2005

Stahelin Robert V, Hwang Jeong H, Kim Jin-Hahn, Park Zee-Yong, Johnson Korey R, Obeid Lina M, Cho Wonhwa

Abstract excerpt

Sphingosine 1-phosphate is a bioactive sphingolipid that regulates cell growth and suppresses programmed cell death. The biosynthesis of sphingosine 1-phosphate is catalyzed by sphingosine kinase (SK) but the mechanism by which the subcellular localization and activity of SK is regulated in response to various stimuli is not fully understood. To elucidate the origin and structural determinant of the specific...

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Identifiers

PMID: 16243846
DOI: 10.1074/jbc.M507574200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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