Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.

The Journal of experimental medicine - 3 Jan 2005

Pitson Stuart M, Xia Pu, Leclercq Tamara M, Moretti Paul A B, Zebol Julia R, Lynn Helen E, Wattenberg Binks W, Vadas Mathew A

Abstract excerpt

Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in mammalian cells, including enhanced proliferation, inhibition of apoptosis, and oncogenesis. Human SK (hSK) 1 possesses high instrinsic catalytic activity which can be further increased by a diverse array of cellular agonists. We have shown previously that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Membrane

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Proliferation

Share to Cell Transformation, Neoplastic

Share to Fluorescent Antibody Technique

Share to Phosphorylation

Share to Phosphotransferases (Alcohol Group Acceptor)

Share to Protein Transport

Source

Open in PubMed Open full text

Identifiers

PMID: 15623571
DOI: 10.1084/jem.20040559
PMCID: PMC2212769

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling.PMID 15623571Read ↗

The mechanism of membrane targeting of human sphingosine kinase 1.Semantic proximity Read ↗

The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane.Semantic proximity Read ↗

Structural dynamics of sphingosine kinase 1 regulation and inhibitionSemantic proximity Read ↗

Structural dynamics of sphingosine kinase 1 regulation and inhibitionSemantic proximity Read ↗

K27Q/K29Q mutations in sphingosine kinase 1 attenuate high-fat diet induced obesity and altered glucose homeostasis in mice.Semantic proximity Read ↗

Mouse Sphingosine Kinase 1a Is Negatively Regulated through Conventional PKC-Dependent Phosphorylation at S373 Residue.Semantic proximity Read ↗

Acid Ceramidase: A Novel Therapeutic Target in CancerSemantic proximity Read ↗

The nucleotide-binding site of human sphingosine kinase 1.Semantic proximity Read ↗

The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells.Semantic proximity Read ↗

A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties.Semantic proximity Read ↗

Molecular Targeting of Acid Ceramidase: Implications to Cancer TherapySemantic proximity Read ↗

Tyrosine sulphation of sphingosine 1-phosphate 1 (S1P1) is required for S1P-mediated cell migration in primary cultures of human umbilical vein endothelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.