Article

Structural dynamics of sphingosine kinase 1 regulation and inhibition

2025-10-09

Abstract excerpt

Sphingosine kinase 1 (SK1) generates sphingosine-1-phosphate, a bioactive lipid implicated in cancer and other diseases. Despite its clinical importance, the structural and dynamic basis of SK1 regulation and inhibition remains poorly understood. Using integrated spectroscopic and computational approaches, we uncover conformational transitions that govern substrate entry, catalysis, and inhibitor binding. Phosphor...

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Literature Corpus work: 1381d196-dbee-5991-a466-648ad9b808ec
DOI: 10.1101/2025.10.09.681406

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