Turning T-cell receptor beta recombination on and off: more questions than answers.

doi:10.1111/j.0105-2896.2006.00342.x

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Article

Turning T-cell receptor beta recombination on and off: more questions than answers.

Immunological reviews - 1 Feb 2006

Jackson Annette M, Krangel Michael S

Abstract excerpt

Successful V(D)J recombination at the T-cell receptor beta (Tcrb) locus is critical for early thymocyte development. The locus is subject to a host of regulatory mechanisms that impart a strict developmental order to Tcrb recombination events and that insure that Tcrb recombination occurs in an allelically excluded fashion. Progress has been made in the understanding of the cis-acting control of Tcrb locus...

Topics

Alleles
Animals
Feedback, Physiological
Gene Expression Regulation, Developmental
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Humans
Lymphopoiesis
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland
VDJ Recombinases

Source

Open in PubMed

Identifiers

PMID: 16448539
DOI: 10.1111/j.0105-2896.2006.00342.x

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