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Article

A role for MAPK in feedback inhibition of Tcrb recombination.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2006

Jackson Annette M, Krangel Michael S

Abstract excerpt

The Tcrb locus is subject to a host of regulatory mechanisms that impart a strict cell and developmental stage-specific order to variable (V), diversity (D), and joining (J) gene segment recombination. The Tcrb locus is also regulated by allelic exclusion mechanisms, which restrict functional rearrangements to a single allele. The production of a functional rearrangement in CD4-CD8- double-negative (DN)...

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Source

Identifiers

PMID: 16709842
DOI: 10.4049/jimmunol.176.11.6824

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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