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Article

Regulation of V(D)J recombination.

Current opinion in immunology - 1 Apr 2006

Spicuglia Salvatore, Franchini Don Marc, Ferrier Pierre

Abstract excerpt

Adaptive immunity is intimately linked to the expression of antigen-specific immunoglobulin and T cell receptor genes and their recombination assembly from germline V, D and J gene segments. This developmentally regulated process relies on the activity of the Rag1-Rag2 recombinase, on accessibility of target gene segments and on monoallelic gene activation. Recent studies have revealed new mechanisms that, along...

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PMID: 16459067
DOI: 10.1016/j.coi.2006.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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