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Article

Allele-specific regulation of TCR beta variable gene segment chromatin structure.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2005

Jackson Annette M, Krangel Michael S

Abstract excerpt

Allelic exclusion of the murine Tcrb locus is imposed at the level of recombination and restricts each cell to produce one functional VDJbeta rearrangement. Allelic exclusion is achieved through asynchronous Vbeta to DJbeta recombination as well as feedback inhibition that terminates recombination once a functional rearrangement has occurred. Because the accessibility of Vbeta gene segment chromatin is diminished...

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Share to Cells, Cultured
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Genes, T-Cell Receptor beta

Share to Mice, Inbred C57BL

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Source

Identifiers

PMID: 16210623
DOI: 10.4049/jimmunol.175.8.5186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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