Article
Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.
Advances in experimental medicine and biology - 1 Jan 2009
Bonnet Marie, Ferrier Pierre, Spicuglia Salvatore
Abstract excerpt
The V(D)J recombination machinery assembles antigen receptor genes from germline V, D and J segments duringlymphocyte development. In alphabetaT cells, this leads to the production of the T-cell receptor (TCR) alpha and beta chains. Notably, V(D)J recombination at the Tcrb locus is tightly controlled at various levels, including cell-type and stage specificities, intralocus ordering and allelic exclusion....
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