Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development.

Advances in experimental medicine and biology - 1 Jan 2009

Johnson Kristen, Reddy Karen L, Singh Harinder

Abstract excerpt

The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig) genes. Recently, considerable progress has been achieved in assembling gene regulatory networks comprised of signaling components and transcription factors that regulate B-cell development. In this chapter we synthesize experimental evidence to explain how such signaling pathways and transcription factors can orchestrate the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Gene Rearrangement, B-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Immunoglobulin

Share to Immunoglobulin Light Chains

Share to Immunoglobulin Variable Region

Share to Recombination, Genetic

Share to Signal Transduction

Share to Transcription Factors

Source

Identifiers

PMID: 19731807
DOI: 10.1007/978-1-4419-0296-2_11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development.PMID 19731807Read ↗

Large-scale chromatin remodeling at the immunoglobulin heavy chain locus: a paradigm for multigene regulation.Semantic proximity Read ↗

Regulation of V(D)J recombination.Semantic proximity Read ↗

Dynamic regulation of antigen receptor gene assembly.Semantic proximity Read ↗

B cell development: transcriptional regulation and immunological mechanisms in homeostasisSemantic proximity Read ↗

Epigenetic control of Tcrb gene rearrangement.Semantic proximity Read ↗

MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUSSemantic proximity Read ↗

Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.Semantic proximity Read ↗

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.Semantic proximity Read ↗

RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.Semantic proximity Read ↗

Genetic and epigenetic control of V gene rearrangement frequency.Semantic proximity Read ↗

Chromatin topology and the regulation of antigen receptor assembly.Semantic proximity Read ↗

Molecular Regulation of Differentiation in Early B-Lymphocyte DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.