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Article

Gene segment selection in V(D)J recombination: accessibility and beyond.

Nature immunology - 1 Jul 2003

Krangel Michael S

Abstract excerpt

V(D)J recombination assembles genes encoding antigen receptors according to defined developmental programs in immature B and T lymphocytes. The 'accessibility hypothesis' was initially invoked to explain how a single recombinase complex could control the locus and allele specificity of V(D)J recombination. It has been since shown that recombination signal sequences themselves influence recombination efficiency...

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Share to Chromatin
Share to CpG Islands
Share to Enhancer Elements, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Genes, Immunoglobulin

Share to Immunoglobulin Joining Region

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 12830137
DOI: 10.1038/ni0703-624

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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