Article
Lymphocyte antigen receptor gene assembly: multiple layers of regulation.
Immunologic research - 1 Jan 2005
Sleckman Barry P
Abstract excerpt
Lymphocyte antigen receptor genes are assembled through the cutting and joining of segments of DNA in developing lymphocytes. The basic features of the biochemical steps of this assembly process, referred to as the V(D)J recombination, are similar for the assembly of all lymphocyte antigen receptor genes, yet this assembly is precisely regulated in several important contexts during lymphocyte development. It has...
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