Article
Promoters, enhancers, and transcription target RAG1 binding during V(D)J recombination.
The Journal of experimental medicine - 20 Dec 2010
Ji Yanhong, Little Alicia J, Banerjee Joydeep K, Hao Bingtao, Oltz Eugene M, Krangel Michael S, Schatz David G
Abstract excerpt
V(D)J recombination assembles antigen receptor genes in a well-defined order during lymphocyte development. This sequential process has long been understood in the context of the accessibility model, which states that V(D)J recombination is regulated by controlling the ability of the recombination machinery to gain access to its chromosomal substrates. Indeed, many features of "open" chromatin correlate with...
Topics
- Acetylation
- Animals
- Binding, Competitive
- Chromatin Immunoprecipitation
- DNA
- Enhancer Elements, Genetic
- Female
- Gene Rearrangement
- Genes, Immunoglobulin
- Genotype
- HMGB1 Protein
- Histones
- Homeodomain Proteins