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Article

Chromatin topology and the regulation of antigen receptor assembly.

Annual review of immunology - 1 Jan 2012

Bossen Claudia, Mansson Robert, Murre Cornelis

Abstract excerpt

During an organism's ontogeny and in the adult, each B and T lymphocyte generates a unique antigen receptor, thereby creating the organism's ability to respond to a vast number of different antigens. The antigen receptor loci are organized into distinct regions that contain multiple variable (V), diversity (D), and/or joining (J) and constant (C) coding elements that are scattered across large genomic regions. In...

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Identifiers

PMID: 22224771
DOI: 10.1146/annurev-immunol-020711-075003

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