Article
Epigenetic control of Tcrb gene rearrangement.
Seminars in immunology - 1 Dec 2010
Spicuglia Salvatore, Pekowska Aleksandra, Zacarias-Cabeza Joaquin, Ferrier Pierre
Abstract excerpt
V(D)J recombination assembles antigen receptor genes from germline V, D and J segments during lymphocyte development. In αβT-cells, this leads to the subsequent expression of T-cell receptor (TCR) β and α chains. Generally, V(D)J recombination is closely controlled at various levels, including cell-type and cell-stage specificities, order of locus/gene segment recombination, and allele usage to mediate allelic...
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