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Article

Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression.

Biological psychiatry - 15 Feb 2006

Gizatullin Rinat, Zaboli Ghazal, Jönsson Erik G, Asberg Marie, Leopardi Rosario

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT) and might be related to the pathogenesis of major depression (MD). Two isoforms are known, TPH-1 and TPH-2. Tryptophan hydroxylase-1 association with MD is still debated. METHODS: A single nucleotide polymorphism (SNP) screening strategy was used to define TPH-1 haplotypes spanning over 23 kilobase (kb) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16165107
DOI: 10.1016/j.biopsych.2005.07.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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