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Article

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients.

Psychopharmacology - 1 Feb 2011

Wang Hsuan-Chi, Yeh Tzung Lieh, Chang Hui Hua, Gean Po Wu, Chi Mei Hung, Yang Yen Kuang, Lu Ru-Band, Chen Po See

Abstract excerpt

RATIONALE: Tryptophan hydroxylase 1 (TPH1), which encodes the rate-limiting enzyme tryptophan hydroxylase in the biosynthesis of serotonin, is a candidate gene in the development and treatment response of major depressive disorder (MDD); however, its actual role is uncertain. OBJECTIVES: We aimed to compare the allele frequencies of TPH1 in MDD patients and healthy controls in Taiwan, and also to investigate the...

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Source

Identifiers

PMID: 20945066
DOI: 10.1007/s00213-010-2034-1

Genes

TPH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients.PMID 20945066Read ↗

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Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Semantic proximity Read ↗

TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response.Semantic proximity Read ↗

Association between the tryptophan hydroxylase-1 gene A218C polymorphism and citalopram antidepressant response in a Korean population.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Tryptophan hydroxylase gene polymorphism (A218C) and suicidal behaviors.Semantic proximity Read ↗

Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

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