Article
Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy.
Journal of psychiatric research - 1 Sept 2012
Fasching Peter A, Faschingbauer Florian, Goecke Tamme W, Engel Anne, Häberle Lothar, Seifert Anna, Voigt Franziska, Amann Manuela, Rebhan Dirk, Burger Pascal, Kornhuber Johannes, Ekici Arif B, Beckmann Matthias W, Binder Elisabeth B
Abstract excerpt
BACKGROUND: A number of studies indicate that altered serotonergic transmission may be a risk factor for depression in the peripartum period. The aim of this study was to investigate whether genetic polymorphisms in the TPH2 gene, the gene product of which is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system, are associated with depressive symptoms in pregnancy and the...
Topics
- Cohort Studies
- Depression, Postpartum
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Phenotype
- Polymorphism, Single Nucleotide
- Pregnancy
- Pregnancy Complications
- Psychiatric Status Rating Scales