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Article

Tryptophan hydroxylase-1 gene variants associated with schizophrenia.

Biological psychiatry - 15 Sept 2006

Zaboli Ghazal, Jönsson Erik G, Gizatullin Rinat, Asberg Marie, Leopardi Rosario

Abstract excerpt

BACKGROUND: Serotonin (5-HT) has been implicated in the pathophysiology of schizophrenia. Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), and as such it might be related to the pathogenesis of schizophrenia. Two isoforms are known, TPH-1 and TPH-2...

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Identifiers

PMID: 16806098
DOI: 10.1016/j.biopsych.2006.03.033

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16806098-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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