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Article

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.

Journal of affective disorders - 1 Apr 2008

Gizatullin Rinat, Zaboli Ghazal, Jönsson Erik G, Asberg Marie, Leopardi Rosario

Abstract excerpt

BACKGROUND: Serotonin (5-HT) has been implicated in the pathophysiology of several psychiatric disorders including major depression (MD). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), and might be related to the pathogenesis of MD. Two isoforms are known, TPH-1 and TPH-2. Their association with MD is still debated. METHODS: A case-control design was used for...

Topics

Adult
Depressive Disorder, Major
Female
Gene Frequency
Genetic Variation
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Isoforms

Psychiatric Status Rating Scales

Stress, Psychological

Tryptophan Hydroxylase

Source

Identifiers

PMID: 17692928
DOI: 10.1016/j.jad.2007.07.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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