Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.

Journal of cellular and molecular medicine - 1 Mar 2018

Wigner Paulina, Czarny Piotr, Synowiec Ewelina, Bijak Michał, Białek Katarzyna, Talarowska Monika, Galecki Piotr, Szemraj Janusz, Sliwinski Tomasz

Abstract excerpt

Tryptophan catabolites pathway disorders are observed in patients with depression. Moreover, single nucleotide polymorphisms of tryptophan hydroxylase genes may modulate the risk of depression occurrence. The objective of our study was to confirm the association between the presence of polymorphic variants of TPH1 and TPH2 genes, and the development of depressive disorders. Six polymorphisms were selected:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Depressive Disorder

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 29314569
DOI: 10.1111/jcmm.13459
PMCID: PMC5824396

Genes

TPH1
TPH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.PMID 29314569Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Meta-analysis of association between TPH2 single nucleotide poiymorphism and depression.Semantic proximity Read ↗

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Semantic proximity Read ↗

Association of tryptophan hydroxylase gene polymorphism with depression, anxiety and comorbid depression and anxiety in a population-based sample of postpartum Taiwanese women.Semantic proximity Read ↗

SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.Semantic proximity Read ↗

Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression.Semantic proximity Read ↗

Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.Semantic proximity Read ↗

Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.Semantic proximity Read ↗

Association between the TPH1 A218C polymorphism and risk of mood disorders and alcohol dependence: evidence from the current studies.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.