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Article

Polymorphism screening and haplotype analysis of the tryptophan hydroxylase gene (TPH1) and association with bipolar affective disorder in Taiwan.

BMC medical genetics - 31 Mar 2005

Lai Te-Jen, Wu Chia-Yen, Tsai Hsu-Wen, Lin Yi-Mei J, Sun H Sunny

Abstract excerpt

BACKGROUND: Disturbances in serotonin neurotransmission are implicated in the etiology of many psychiatric disorders, including bipolar affective disorder (BPD). The tryptophan hydroxylase gene (TPH), which codes for the enzyme catalyzing the rate-limiting step in serotonin biosynthetic pathway, is one of the leading candidate genes for psychiatric and behavioral disorders. In a preliminary study, we found that...

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Source

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Identifiers

PMID: 15799788
DOI: 10.1186/1471-2350-6-14
PMCID: PMC1079843

Genes

TPH1
TPH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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