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Article

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.

Neuroscience and biobehavioral reviews - 1 Sept 2018

Ottenhof Koen Willem, Sild Mari, Lévesque Mélissa Luce, Ruhé Henricus Gerardus, Booij Linda

Abstract excerpt

Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain serotonin synthesis. The TPH2 gene has frequently been investigated in relation to psychiatric morbidity. The aim of the present review is to integrate results from association studies between TPH2 single nucleotide polymorphisms (SNPs) and various psychiatric disorders, which we furthermore quantified with meta-analysis. We reviewed 166 studies...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29775696
DOI: 10.1016/j.neubiorev.2018.05.018

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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