Article
SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.
Molecular psychiatry - 1 Nov 2004
Zill P, Baghai T C, Zwanzger P, Schüle C, Eser D, Rupprecht R, Möller H-J, Bondy B, Ackenheil M
Abstract excerpt
Tryptophan hydroxylase (TPH), being the rate-limiting enzyme in the biosynthesis of serotonin plays a major role as candidate gene in several psychiatric disorders. Recently, a second TPH isoform (TPH2) was identified in mice, which was exclusively present in the brain. In a previous post-mortem study of our own group, we could demonstrate that TPH2 is also expressed in the human brain, but not in peripheral...
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