Article
TPH2 gene polymorphisms and major depression--a meta-analysis.
PloS one - 1 Jan 2012
Gao Jin, Pan Zhenglun, Jiao Zhian, Li Feng, Zhao Guoqing, Wei Qianqian, Pan Fang, Evangelou Evangelos
Abstract excerpt
BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced...
Topics
- Depressive Disorder, Major
- Genome-Wide Association Study
- Humans
- Polymorphism, Single Nucleotide
- Tryptophan Hydroxylase