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Article

TPH2 gene polymorphisms and major depression--a meta-analysis.

PloS one - 1 Jan 2012

Gao Jin, Pan Zhenglun, Jiao Zhian, Li Feng, Zhao Guoqing, Wei Qianqian, Pan Fang, Evangelou Evangelos

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase-2 (TPH2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (CNS). Gene-disease association studies have reported a relationship between TPH2 and major depressive disorder (MDD) in different populations, however subsequent studies have produced...

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Identifiers

PMID: 22693556
DOI: 10.1371/journal.pone.0036721
PMCID: PMC3365065

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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