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Article

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.

Molecular psychiatry - 1 Aug 2008

Haghighi F, Bach-Mizrachi H, Huang Y Y, Arango V, Shi S, Dwork A J, Rosoklija G, Sheng H T, Morozova I, Ju J, Russo J J, Mann J J

Abstract excerpt

Impaired brain serotonin neurotransmission is a potential component of the diathesis of major depression. Tryptophan hydroxylase-2 (TPH2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. Here, we identify a novel TPH2 short isoform with truncated catalytic domain expressed in human brainstem, prefrontal cortex,...

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Identifiers

PMID: 18180764
DOI: 10.1038/sj.mp.4002127

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.PMID 18180764Read ↗

A functional alternative splicing mutation in human tryptophan hydroxylase-2.Semantic proximity Read ↗

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.Semantic proximity Read ↗

Haplotype analysis reveals tryptophan hydroxylase (TPH) 1 gene variants associated with major depression.Semantic proximity Read ↗

A common microdeletion affecting a hippocampus- and amygdala-specific isoform of tryptophan hydroxylase 2 is not associated with affective disorders.Semantic proximity Read ↗

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.Semantic proximity Read ↗

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