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Article

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.

Progress in neuro-psychopharmacology & biological psychiatry - 15 Jun 2009

Tsai Shih-Jen, Hong Chen-Jee, Liou Ying-Jay, Yu Younger W-Y, Chen Tai-Jui, Hou Sheue-Jane, Yen Feng-Chang

Abstract excerpt

Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whether common genetic variation in the TPH2 gene is associated with MDD and therapeutic response to antidepressants in a...

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Source

Identifiers

PMID: 19272410
DOI: 10.1016/j.pnpbp.2009.02.020

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.PMID 19272410Read ↗

Tryptophan hydroxylase 2 gene is associated with major depressive disorder in a female Chinese population.Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

TPH1 is associated with major depressive disorder but not with SSRI/SNRI response in Taiwanese patients.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia.Semantic proximity Read ↗

TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

No association between the tryptophan hydroxylase gene polymorphism and major depressive disorders and antidepressant response in a Korean population.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

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