Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.

doi:10.1016/j.pnpbp.2009.02.020

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Article

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.

Progress in neuro-psychopharmacology & biological psychiatry - 15 Jun 2009

Tsai Shih-Jen, Hong Chen-Jee, Liou Ying-Jay, Yu Younger W-Y, Chen Tai-Jui, Hou Sheue-Jane, Yen Feng-Chang

Abstract excerpt

Tryptophan hydroxylase-2 (TPH2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (MDD) and in the mechanism of antidepressant action. This study aimed to investigate whether common genetic variation in the TPH2 gene is associated with MDD and therapeutic response to antidepressants in a...

Topics

Adult
Antidepressive Agents
Citalopram
Depressive Disorder, Major
Female
Fluoxetine
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide
Selective Serotonin Reuptake Inhibitors

Source

Open in PubMed

Identifiers

PMID: 19272410
DOI: 10.1016/j.pnpbp.2009.02.020

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Taiwan

Tryptophan Hydroxylase