Article
Genome-wide association data provide further support for an association between 5-HTTLPR and major depressive disorder.
Journal of affective disorders - 25 Apr 2013
Haenisch Britta, Herms Stefan, Mattheisen Manuel, Steffens Michael, Breuer Rene, Strohmaier Jana, Degenhardt Franziska, Schmäl Christine, Lucae Susanne, Maier Wolfgang, Rietschel Marcella, Nöthen Markus M, Cichon Sven
Abstract excerpt
BACKGROUND: Dysfunctions of serotonergic neurotransmission are supposed to be involved in the pathogenesis of psychiatric disorders such as major depressive disorder (MDD). The concentration of serotonin (5-hydroxytryptamine, 5-HT) in the synaptic cleft is essentially regulated by the 5-HT transporter (5-HTT). A length polymorphism repeat in the 5-HTT promoter region, termed 5-HTTLPR, has been commonly...
Topics
- Adult
- Case-Control Studies
- Depressive Disorder, Major
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Germany
- Haplotypes
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide