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Article

Functional characterization of 32 CYP2C9 allelic variants.

The pharmacogenomics journal - 1 Apr 2014

Niinuma Y, Saito T, Takahashi M, Tsukada C, Ito Mi, Hirasawa N, Hiratsuka M

Abstract excerpt

Genetic variations in cytochrome P450 2C9 (CYP2C9) contribute to interindividual variability in the metabolism of clinically used drugs such as warfarin and tolbutamide. We functionally characterized 32 types of allelic variant CYP2C9 proteins. Recombinant CYP2C9 proteins generated using a heterologous expression system are useful for comparing functional changes in CYP2C9 variant proteins expressed from...

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Identifiers

PMID: 23752738
DOI: 10.1038/tpj.2013.22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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