Article
Identification and partial characterization of a novel CYP2C9 splicing variant encoding a protein lacking eight amino acid residues.
Drug metabolism and pharmacokinetics - 1 Jun 2007
Ariyoshi Noritaka, Shimizu Yoko, Kobayashi Yukari, Nakamura Hiroyoshi, Nakasa Hiromitsu, Nakazawa Kazuyoshi, Ishii Itsuko, Kitada Mitsukazu
Abstract excerpt
CYP2C9 is known as an enzyme responsible for the metabolism of various clinically important drugs. Recently, we cloned a cDNA corresponding to a CYP2C9 splicing variant (SV), which seemed to have an open reading frame of a protein with 482 amino acid residues. To investigate whether or not the SV can be translated as a functionally active protein, we expressed the CYP2C9SV in insect cells, and spectrophotometric...
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