Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification and functional characterization of new potentially defective alleles of human CYP2C19.

Pharmacogenetics - 1 Dec 2002

Blaisdell Joyce, Mohrenweiser Harvey, Jackson Jonathan, Ferguson Stephen, Coulter Sherry, Chanas Brian, Xi Tina, Ghanayem Burhan, Goldstein Joyce A

Abstract excerpt

CYP2C19 is a clinically important enzyme responsible for the metabolism of a number of therapeutic drugs, such as mephenytoin, omeprazole, diazepam, proguanil, propranolol and certain antidepressants. Genetic polymorphisms in this enzyme result in poor metabolizers of these drugs. There are racial differences in the incidence of the poor metabolizer trait, which represents 13-23% of Asians but only 3-5% of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Black or African American

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Black People

Share to Cytochrome P-450 CYP2C19

Share to Ethnicity

Share to Mephenytoin

Share to Mixed Function Oxygenases

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 12464799
DOI: 10.1097/00008571-200212000-00004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification and functional characterization of new potentially defective alleles of human CYP2C19.PMID 12464799Read ↗

Discovery of new potentially defective alleles of human CYP2C9.Semantic proximity Read ↗

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.Semantic proximity Read ↗

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.Semantic proximity Read ↗

A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin.Semantic proximity Read ↗

Clinical relevance of genetic polymorphisms in the human CYP2C subfamily.Semantic proximity Read ↗

Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy.Semantic proximity Read ↗

In Vitro Functional Characterisation of Cytochrome P450 (CYP) 2C19 Allelic Variants CYP2C19*23 and CYP2C19*24.Semantic proximity Read ↗

Impact of Genetic Polymorphisms in CYP2C9 and CYP2C19 on the Pharmacokinetics of Clinically Used DrugsSemantic proximity Read ↗

Clinical Application of CYP2C19 Pharmacogenetics Toward More Personalized MedicineSemantic proximity Read ↗

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.Semantic proximity Read ↗

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.Semantic proximity Read ↗

Identification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.