Article
Identification of a novel variant CYP2C9 allele in Chinese.
Pharmacogenetics - 1 Jul 2004
Si Dayong, Guo Yingjie, Zhang Yifan, Yang Lei, Zhou Hui, Zhong Dafang
Abstract excerpt
OBJECTIVES: Cytochrome P450 (CYP) 2C9 metabolizes about 16% of drugs in current clinical use, including lornoxicam and tolbutamide. SNPs in the CYP2C9 gene have increasingly been recognized as determinants of the metabolic phenotype that underlies interindividual and ethnic differences. METHODS: The present study focused on a Chinese poor metabolizer (PM) whose apparent genotype (CYP2C9*1/CYP2C9*3) did not agree...
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