Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.

Drug metabolism and disposition: the biological fate of chemicals - 1 Nov 2009

Lee Su-Jun, Kim Woo-Young, Kim Hyunmi, Shon Ji-Hong, Lee Sang Seop, Shin Jae-Gook

Abstract excerpt

Although many cases of interindividual variation in the metabolism of CYP2C19 drugs are explained by the CYP2C19*2, *3, and *17, a wide range of metabolic variation still occurs in people who do not carry these genetic variants. The objectives of this study were to identify new genetic variants and to characterize functional consequences of these variants in metabolism of CYP2C19 substrates. In total, 21...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aryl Hydrocarbon Hydroxylases
Share to Cattle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Enzyme Activation

Share to Mephenytoin

Share to Omeprazole

Share to Random Allocation

Share to Substrate Specificity

Source

Identifiers

PMID: 19661214
DOI: 10.1124/dmd.109.028175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of new CYP2C19 variants exhibiting decreased enzyme activity in the metabolism of S-mephenytoin and omeprazole.PMID 19661214Read ↗

Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.Semantic proximity Read ↗

Identification and functional characterization of new potentially defective alleles of human CYP2C19.Semantic proximity Read ↗

Discovery of new potentially defective alleles of human CYP2C9.Semantic proximity Read ↗

In vitro functional analysis of 24 novel CYP2C19 variants recently found in the Chinese Han population.Semantic proximity Read ↗

Identification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population.Semantic proximity Read ↗

Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han populationSemantic proximity Read ↗

In Vitro Functional Characterisation of Cytochrome P450 (CYP) 2C19 Allelic Variants CYP2C19*23 and CYP2C19*24.Semantic proximity Read ↗

Molecular functionality of CYP2C9 polymorphisms and their influence on drug therapy.Semantic proximity Read ↗

Identification of new human CYP2C19 alleles (CYP2C19*6 and CYP2C19*2B) in a Caucasian poor metabolizer of mephenytoin.Semantic proximity Read ↗

Clinical Application of CYP2C19 Pharmacogenetics Toward More Personalized MedicineSemantic proximity Read ↗

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese.Semantic proximity Read ↗

A new genetic defect in human CYP2C19: mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.