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Article

[Loss of heterozygosity induced by cyclophosphamide at tk locus in human lymphoblastoid cell line TK6].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 1 May 2005

Zhan Li, Zhang Li-shi, Wang Li, Zhang Hao, Takayoshi Suzuki, Masamitsu Honma, Wu De-sheng

Abstract excerpt

OBJECTIVE: Human lymphoblastoid cell line TK6 was used to investigate TK gene mutation frequency and the loss of heterozygosity (LOH) induced by cyclophosphamide (CP). METHODS: Relative survival, mutation frequency at tk locus induced by CP (+S9) after 4 h treatment were detected. DNA isolated from mutants in the control culture and CP treatment group was analyzed for LOH. RESULTS: Exposure to CP for 4 h...

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PMID: 15931861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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