Article
Spontaneous mutation spectrum in the hprt gene in human lymphoblastoid TK6 cells.
Mutagenesis - 1 Mar 1995
Lichtenauer-Kaligis E G, Thijssen J C, den Dulk H, van de Putte P, Giphart-Gassler M, Tasseron-de Jong J G
Abstract excerpt
A spectrum of 100 mutations in the endogenous hprt gene of the human lymphoblastoid TK6 cell line is presented. The majority of the mutations originates in sequences outside the coding region of the gene. Large deletions are a major cause of inactivation of the hprt gene (57% of the mutants). Mutations in the splice sites that result in several forms of aberrantly spliced mRNA are relatively frequently recovered...
Topics
- Base Sequence
- Cell Line
- Codon
- Genes
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation