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Article

Increased transcription decreases the spontaneous mutation rate at the thymidine kinase locus in human cells.

Mutation research - 5 Jun 1998

Lippert M J, Chen Q, Liber H L

Abstract excerpt

Transcription increases DNA repair efficiency and modulates the distribution of certain types of DNA damage. Furthermore, increased transcription level stimulates spontaneous mutation rate in yeast. We explored whether transcription level affects spontaneous mutation rate in human cells. We first developed two thymidine kinase (tk) inducible human cell lines using the Gal4-Estrogen receptor system. In our TK6i-G3...

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PMID: 9639662
DOI: 10.1016/s0027-5107(98)00011-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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