Article
Increased transcription decreases the spontaneous mutation rate at the thymidine kinase locus in human cells.
Mutation research - 5 Jun 1998
Lippert M J, Chen Q, Liber H L
Abstract excerpt
Transcription increases DNA repair efficiency and modulates the distribution of certain types of DNA damage. Furthermore, increased transcription level stimulates spontaneous mutation rate in yeast. We explored whether transcription level affects spontaneous mutation rate in human cells. We first...
Topics
- B-Lymphocytes
- Cell Line
- DNA Repair
- DNA-Binding Proteins
- Electroporation
- Enzyme Induction
- Estradiol
- Fungal Proteins
- Heterozygote
- Humans
- Kinetics
- Mutation
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Receptors, Estrogen
- Recombinant Fusion Proteins
- Saccharomyces cerevisiae Proteins
- Thymidine Kinase