Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation induction in cultured human cells after low-dose and low-dose-rate gamma-ray irradiation: detection by LOH analysis.

Journal of radiation research - 1 Jan 2007

Umebayashi Yukihiro, Honma Masamitsu, Suzuki Masao, Suzuki Hiromi, Shimazu Toru, Ishioka Noriaki, Iwaki Masaya, Yatagai Fumio

Abstract excerpt

To study the genetic effects of low-doses and low-dose-rate ionizing radiation (IR), human lymphoblastoid TK6 cells were exposed to 30 mGy of gamma-rays at a dose-rate of 1.2 mGy/hr. The frequency of early mutations (EMs) in the thymidine kinase (TK) gene locus was determined to be 1.7 x 10(-6), or 1.9-fold higher than the level seen in unirradated controls. These mutations were analyzed with a loss of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dose-Response Relationship, Radiation
Share to Genetic Carrier Screening

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

Share to Lymphocytes

Share to Radiation Dosage

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Share to Thymidine Kinase

Source

Identifiers

PMID: 17132913
DOI: 10.1269/jrr.06054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation induction in cultured human cells after low-dose and low-dose-rate gamma-ray irradiation: detection by LOH analysis.PMID 17132913Read ↗

Detection of genetic alterations induced by low-dose X rays: analysis of loss of heterozygosity for TK mutation in human lymphoblastoid cells.Semantic proximity Read ↗

Mutagenic radioadaptation in a human lymphoblastoid cell line.Semantic proximity Read ↗

Sensitive detection of LOH events in a human cell line after C-ion beam exposure.Semantic proximity Read ↗

Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro.Semantic proximity Read ↗

Frozen human cells can record radiation damage accumulated during space flight: mutation induction and radioadaptation.Semantic proximity Read ↗

A comparison of induced mutation at homologous alleles of the tk locus in human cells.Semantic proximity Read ↗

Mutational spectrum of X-ray induced TK- human cell mutants.Semantic proximity Read ↗

Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells.Semantic proximity Read ↗

A comparison of induced mutation at homologous alleles of the tk locus in human cells. II. Molecular analysis of mutants.Semantic proximity Read ↗

Ionizing radiation signature mutations in human cell mutants induced by low-dose exposures.Semantic proximity Read ↗

Detection of adaptive response at chromosome level.Semantic proximity Read ↗

Radiation specific patterns of loss of heterozygosity on chromosome 17q.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.