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Article

Mutation induction in cultured human cells after low-dose and low-dose-rate gamma-ray irradiation: detection by LOH analysis.

Journal of radiation research - 1 Jan 2007

Umebayashi Yukihiro, Honma Masamitsu, Suzuki Masao, Suzuki Hiromi, Shimazu Toru, Ishioka Noriaki, Iwaki Masaya, Yatagai Fumio

Abstract excerpt

To study the genetic effects of low-doses and low-dose-rate ionizing radiation (IR), human lymphoblastoid TK6 cells were exposed to 30 mGy of gamma-rays at a dose-rate of 1.2 mGy/hr. The frequency of early mutations (EMs) in the thymidine kinase (TK) gene locus was determined to be 1.7 x 10(-6), or 1.9-fold higher than the level seen in unirradated controls. These mutations were analyzed with a loss of...

Topics

Cell Line
DNA Mutational Analysis
Dose-Response Relationship, Radiation
Genetic Carrier Screening
Humans
Loss of Heterozygosity
Lymphocytes
Mutation
Radiation Dosage
Reproducibility of Results

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sensitivity and Specificity

Thymidine Kinase

Source

Identifiers

PMID: 17132913
DOI: 10.1269/jrr.06054

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