Article
Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Apr 2000
Meng Q, Su T, Olivero O A, Poirier M C, Shi X, Ding X, Walker V E
Abstract excerpt
3'-Azido-3'-deoxythymidine (AZT), a thymidine analogue widely used in the treatment of AIDS patients and for prevention of the onset of AIDS in HIV-seropositive individuals, causes tumors in mice exposed as adults or in utero. The purpose of this study was to investigate the potential mechanisms of AZT mutagenicity and carcinogenicity by quantifying the incorporation of AZT into cellular DNA, measuring...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.