Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spectrum of spontaneous HPRT- mutations in TK6 human lymphoblasts.

Environmental and molecular mutagenesis - 1 Jan 1993

Giver C R, Nelson S L, Grosovsky A J

Abstract excerpt

The occurrence of deletions, coding sequence alterations, and intronic changes leading to aberrant splicing has been characterized among 33 spontaneous HPRT- mutants in TK6 human lymphoblasts. Deletions detectable by multiplex PCR amplification accounted for 45% (15/33) of the mutant collection. Base substitutions represented 30% (10/33) of the total, and were predominated by changes at G:C base pairs. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cell Line
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Molecular Sequence Data

Share to Mutation

Share to Point Mutation

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 8404873
DOI: 10.1002/em.2850220305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spectrum of spontaneous HPRT- mutations in TK6 human lymphoblasts.PMID 8404873Read ↗

Spontaneous mutation spectrum in the hprt gene in human lymphoblastoid TK6 cells.Semantic proximity Read ↗

Genome wide spontaneous mutation in human cells determined by the spectrum of mutations in hprt cDNA genes.Semantic proximity Read ↗

Mutational spectrum of X-ray induced TK- human cell mutants.Semantic proximity Read ↗

Mutations causing defective splicing in the human hprt gene.Semantic proximity Read ↗

Molecular spectrum of background mutation at the hprt locus in human T-lymphocytes.Semantic proximity Read ↗

hprt mutations in vivo in human T-lymphocytes: frequencies, spectra and clonality.Semantic proximity Read ↗

Novel types of mutation identified at the hprt locus of human T-lymphocytes.Semantic proximity Read ↗

Splicing mutations at the HPRT locus in human T-lymphocytes in vivo.Semantic proximity Read ↗

DNA-sequence specificity of mutations at the human thymidine kinase locus.Semantic proximity Read ↗

Kinds and locations of mutations arising spontaneously in the coding region of the HPRT gene of finite-life-span diploid human fibroblasts.Semantic proximity Read ↗

Mutations that alter RNA splicing of the human HPRT gene: a review of the spectrum.Semantic proximity Read ↗

Molecular nature of spontaneous mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in Chinese hamster ovary cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.