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Article

Molecular mechanisms of spontaneous and induced loss of heterozygosity in human cells in vitro.

Somatic cell and molecular genetics - 1 Jan 1992

Li C Y, Yandell D W, Little J B

Abstract excerpt

The human TK6 lymphoblast cell line is heteroallelic at the thymidine kinase (TK) locus, with one functional and one nonfunctional allele. Cells that have undergone loss of heterozygosity (LOH) at TK can be selected and cloned in an in vitro assay. In order to study the extent of LOH, we have analyzed a total of 166 thymidine kinase-deficient mutants that arose either spontaneously or following induction by X-ray...

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Identifiers

PMID: 1546370
DOI: 10.1007/BF01233450

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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