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Article

Generation of loss of heterozygosity and its dependency on p53 status in human lymphoblastoid cells.

Environmental and molecular mutagenesis - 1 Jan 2000

Honma Masamitsu

Abstract excerpt

Loss of heterozygosity (LOH) is a critical event in the development of human cancers. LOH is thought to result from either a large deletion or recombination between homologous alleles during repair of DNA double-strand breaks (DSBs). These types of genetic alterations produce mutations in the TK gene mutation assay, which detects a wide mutational spectrum, ranging from point mutations to LOH-type mutations. TK6,...

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Identifiers

PMID: 15688360
DOI: 10.1002/em.20113

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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